Jobs
Pour mettre en ligne des annonces (recrutements ou lab-rotation) contacter
communication[at]paris-neuroscience.com.
A two post doctoral position is available immediately in the group of Dr. Alain Chédotal at the Institut de la Vision in Paris ////// 14 mai 2012
Name of the research group : A two post doctoral position is available immediately in the group of Dr. Alain Chédotal at the Institut de la Vision in Paris, France.The primary research focus of the project will be to study the role of various axon guidance molecules in the development of the visual system (retina and visuomotor system). We are seeking applicants with expertise in time-lapse imaging,and a background in cell signaling of neuronal migration and differentiation. Some expertise in transcriptomics would also be welcome.
Requirements: Candidates must (1) be less than 35 years old, (2) hold a PhD degree in Neuroscience or molecular or cell biology. (3) have at least one 1st author article published in a peer reviewed journal, (4) have a strong knowledge of English, (5) and must not have done another postdoc in France. In addition, we value candidates who demonstrate independent thinking, good organizational skills, and a strong motivation. Qualified candidates are encouraged to email a statement of interest including career objectives, a Curriculum Vitae and contact information for three references to Dr Alain Chédotal (alain.chedotal[at]inserm.fr).
ENP STUDENT LAB ROTATION - EQUIPE DE PIERRE VINCENT - ANYTIME ////// 16 avril 2012Name of the research group:
Cellular Integration of Neuromodulatory Processes
Group leader:
Pierre VINCENT
Research project proposed:
- Spatial propagation of the cAMP/PKA signal through the dendritic tree: two-photon imaging of biosensor and local dopamine uncaging
- Mechanism of action of antipsychotic drugs: cellular effects of novel phosphodiesterase inhibitors and D2 receptor antagonists
Time period of rotation:
Any time. EMPLOI POST DOCTORANT - Equipe de C. Wyart "Dissection optogénétique des circuits spinaux"" ////// 16 avril 2012L'équipe de Claire Wyart ("Dissection optogénétique des circuits spinaux") offre un emploi pour un post-doctorant à l'ICM.
Pré-requis
Recherche d'un candidat travaillant sur OPTIQUE / MACHINERIE / NEUROPHYSIOLOGIE
Team Overview
Les neurobiologistes ont décrits en détail l’anatomie de différents types de cellules dans la moelle épinière. Par des enregistrements corrélationels sur des preparations disséquées, ils ont proposé que les neurones spinaux constituent un centre générateur de rythme qui sous tend l’activité rythmique nécessaire pour la locomotion. Quel est le niveau de spécificité des cellules qui sont recrutés pendant des sequence locomotrices spécifiques? En développant une approche pour controler l’activité neuronale à distance (optogénétique) dans un animal éveillé, nous pouvons sonder le role de neurons spécifiques dans la sortie motrice. Notre équipe a développé des outils pour controler l’activité in vivo, et a appliqué ces outils pour aborder une question intriguante: la function des neurons qui contactent le liquide céphélorachidien (CSFns) dans la moelle épinière des vertébrés. Nous avons démontré que les CSFns pouvaient déclencher la nage lente aux stades précoces du développement. Maintenant notre équipe étudie leurs fonctions sensorielles et reconstruit le circuit auxquels ils appartiennent. De manière plus générale, nous disséquons les circuits sous tendant la locomotion et qui forment ou modulent les générateurs de rythme.
Contact
Contacter claire.wyart[at]icm-institute.org en envoyant :
- votre résumé,
- PDF de vos principales publication en graduate (PhD),
- le nom et le contact de 3 références,
- une lettre de motivation,
- une publication qui vous inspire.
ENP STUDENT LAB ROTATION - J.C. PONCER - SABINE LEVI - ANY TIME ////// Name of the research group: Avenir Team "Plasticity in cortical networks and epilepsy"
Group leader(s): Jean Christophe PONCER, Sabine LEVI
Research project proposed:
Metabotropic receptors are key actors in the control of GABAergic and glutamatergic synaptic transmission during development. Metabotropic adenosine 2A receptors are largely expressed at early developmental stages, but their role during development remains to be explored. Preliminary data show that blockade of A2A receptors decreases GABAergic and glutamatergic neurotransmission. The goal of the project is to investigate the underlying molecular mechanisms, focusing on receptor dynamics in the membrane.
Lateral diffusion plays a key role in controlling receptor content at synapses. Receptors that move freely in the extrasynaptic membrane are trapped to the postsynaptic cytoskeleton through transient interaction with scaffolding molecules. We will check whether depletion in postsynaptic receptor content correlates with i) alteration in membrane dynamics properties of both inhibitory and excitatory receptors and ii) changes in the number of postsynaptic scaffolding molecules at synapses. The impacts of A2A receptor blockade on receptor lateral diffusion and on scaffold composition will be studied with quantum dot based single particle tracking experiments and live videomicroscopy, respectively.
Experimental approaches: live cell imaging, single molecule imaging with quantum dots, immunocytochemistry, confocal microscopy
Time period of rotation: anytime from September 1st, 2011 ENP STUDENT LAB ROTATION - DANIEL SHULZ's GROUP - ANY TIME ////// Name of the research group: Sensory Processing, Neuromodulation and Plasticity
Group leader(s): Daniel E. Shulz
Research project proposed: Propagation of "believes" in a cortical network induced by complex tactile stimuli.
Experimental approaches: In vivo electrophysiology with multiple single-unit recordings and complex spatio-temporal tactile stimuli.
Time period of rotation: any
POST DOCTORAL FELLOW - Nathalie Cartier's team "Genetics and biotherapy for degenerative diseases of the CNS" - JUIN 2012 ////// Name of the research group : Genetics and biotherapy for degenerative diseases of the CNS (INSERM U745 , faculty of Pharmaceutical Sciences , paris Descartes University)
A 18 months Post-doctoral position funded by The Fundation Simone et Cino del Duca is open in the team Biotherapy of degenerative diseases of the nervous system (directed by Nathalie Cartier) at the French National Institute for Health and Medical research (INSERM) UMR 745 :
Biotherapy and Genetics of degenerative and proliferative diseases of the nervous system. This team will be located in the CEA (Fontenay aux Roses) MIRCen that provides cutting-edge equipments for small and large animal experiments.
Technical description : Our group is using viral gene transfer technologies to study the physiopathology, develop models, and brain gene therapy strategies for neurodegenerative diseases from preclinical steps to clinical applications : genetic leukodystrophies (current clinical trial in adrenoleukodystrophy; clinical application starting in 2011 for Metachromatic Leukodystrophy= MLD), Alzheimer (AD). Our ultimate goal is to complete all preclinical steps toward clinical application.
The projects aims at 1) developing and studying a new therapeutic approach for Alzheimer Disease based on vector-targeted therapeutic gene expression to the brain.
Qualifications : Candidate should have a strong background in neuroscience, particularly in cell biology, neuropathology, animal models and cognitive evaluation /or in gene transfer technologies to the brain and viral vectors (lentivirus, AAV). Expertise in hematopoietic stem cells (HSC) and HSC transplantation in mouse, histological and immunohistological procedures, animal surgery (stereotaxy) and dissections of rodent brain regions are expected. Agreement to experiment on living animals would be a major advantage. Moreover, the candidate must have demonstrated strong abilities in leading a research team, autonomy, initiative in carrying out experiments and sense of responsibilities.
The position is available in June 2012.
Terms of position : Net income from 2300 to 2900 €/month depending on the candidate cursus
ENP STUDENT LAB ROTATION - JAMEL CHELLY's GROUP from 01/2012 to 05/2012 //////
Name of the research group: Genetic and pathophysiology of neurodevelopmental diseases
Group leader: Jamel Chelly
Research project proposed:
We are interested in genetic causes involved in unresolved forms of neurodevelopmental disorders, as well as in molecular, biological and cellular processes underlying pathogeny of these disorders.
Projects developed by our team are in continuity with our previous work and rely on scientific strategies that combine complementary genetic and functional approaches. They include:
1. Genetics and pathophysiology of neurodevelopmental disorders (J.Chelly)
Searching and identification of molecular causes and genes involved in neurodevelopemental diseases is focused in particular on :
• Intellectual disability (i.e, non syndromic X-linked and autosomal recessive forms of mental retardation).
• Malformations of cortical development and gyral abnormalities: lissencephaly, pachygyria, polymicrogyria, neuronal heterotopia
2. Pathophysiology of intellectual disability (P.Billuart)
Projects aiming to define biological and cellular processes underlying intellectual disability include:
• Understanding of the role of RhoGTPases pathways on neuronal and synaptic activity with a focus on oligophrenin 1 (OPHN1) function.
• Investigation of the interleukin1 signaling pathway in neuronal and glial cells with a focus on IL1RAPL1 function in the regulation of PSD95 phosphorylation by JNK.
3. Pathophysiology of Rett and Rett-like syndromes (T.Bienvenu)
Contribution into the understanding the function of MeCP2, CDKL5 and FOXG1, three proteins involved in Rett and Rett-like syndromes is achieved through identification of targets of MeCP2, CDKL5 and FOXG1 using non-neuronal and neuronal cellular, as well as molecular and functional approaches.
Experimental approaches: Human genetics ; cellular and molecular approaches ; mouse models of intellectual disabilities
Time period of rotation: 03/2011-09/2011 and 01/2012-05/2012
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